Experimental research on the development of extemporaneous ointment base composition

Authors

DOI:

https://doi.org/10.24959/uekj.20.18

Keywords:

composition, emulsion base, extemporaneous ointment, dermatology

Abstract

It is known that soft medicines, such as ointments, play an important role in the external treatment of skin diseases. This dosage form does not interfere with the natural functions of the skin, effectively moisturizes the absorption surface, eliminates inflammation and itching. And, if the active pharmaceutical ingredients (API) provide the necessary pharmacological action of the medicine, the hydration of the skin surface is achieved through a properly selected ointment base. The type of the base that best meets the task is an emulsion system “oil in water”.

Aim. To develop the emulsion base composition of extemporaneous ointment intended for the use in dermatology.

Materials and methods. Organoleptic, physicochemical, pharmacotechnological, biopharmaceutical and statistical methods have been used in the work.

Results. At the first stage of research, 10 model samples of extemporaneous emulsion bases have been processed, in the composition of which corn oil was introduced as the oil phase. The following surfactants (emulsifiers) used as stabilizers of the emulsion system: polysorbate-80, cetearyl olivate, arachidyl alcohol, emulsifier No. 1, glycerin monostearate. Glycerin and propylene glycol have been used as the hydrophilic phase to provide moderate osmotic activity of the test samples, as well as to prevent overdrying and skin irritation. Colloidal and thermal stability have been determined for model samples of ointment bases, which became homogeneous immediately after preparation. The tested bases have been subjected to pH, osmotic activity and biopharmaceutical studies.

Conclusions. Based on the determination of homogeneity, colloidal, thermal stability, pH, osmotic activity and efficiency of API release from the samples of extemporaneous emulsion bases, the composition of the emulsion base of extemporaneous ointment intended for the use in dermatology has been experimentally substantiated.

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Published

2020-09-10

Issue

Section

Quality, standardization and certification in pharmacy