Rheological researches on the development of the bigels composition for complex mastopathy therapy
DOI:
https://doi.org/10.24959/uekj.20.14Keywords:
rheological studies, bigel, mastopathyAbstract
Aim. To find gel for organogel as a component of the bigel and substantiate the ratio of organo and hydrophilic phase in the composition of the bigel for the complex treatment of mastopathy.
Results. Studies of rheological behavior of the samples (structural-mechanical properties) have been carried out using a rheometerRheolabQC by Anton Paar (Austria) using a coaxial cylinder system C-CC27/SS. The device meets the requirements of the standard ISO 3219. On the basis of the obtained results, the values of the dynamic dilution coefficients of the system have been calculated. Mechanical stability (MS) parameters have been calculated for a more complete characterization of the test specimens. The sample made without the use of organogel in the composition has low structural and mechanical parameters, the type of flow of the system approaches the Newtonian type, which indicates its unfitness for use. The profile of changes in the effective viscosity on the concentration of oranogel has the same dependence, however, the use of the composition Spen 60 and fatty oil of seeds of parsley seeds (15 : 85) provides a higher structural viscosity and generally higher structural and mechanical properties.
Conclusions. A comparative assessment of the rheological properties of bigelmodel samples for mastopathytreatment with different contents of hydrophilic fractions and organophases of a gel made by the classical technology of emulsifying of parsley seed oil PEG-40 hydrogenated with castor oil. The gel-forming agent for the organogel fraction was determined – Spen 60. The optimal ratio of hydro- and organophases in the composition of the bigel, which was 65/35 and 70/30 %, respectively, was substantiated.References
Zuikina, S., & Vyshnevska, L. (2020). Methodology of the development of combined drugs based on medicinal plant materials for mastopathy treatment. Management, Economy And Quality Assurance In Pharmacy, 1(61), 06–13. http://dx.doi.org/10.24959/uekj.20.10
Shakeel, A., Farooq, U., Iqbal, T., Yasin, S., Lupi, F. R., & Gabriele, D. (2019). Key characteristics and modelling of bigels systems: A review. Materials Science and Engineering: C, 97, 932–953. https://doi.org/10.1016/j.msec.2018.12.075
Andonova, V. Y., Peneva, P. T., Apostolova, E. G., Dimcheva, T. D., Peychev, Z. L., & Kassarova, M. I. (2017). Carbopol hydrogel/sorbitan monostearate-almond oil based organogel biphasic formulations: Preparation and characterization of the bigels. Tropical Journal of Pharmaceutical Research, 16(7), 1455. https://doi.org/10.4314/tjpr.v16i7.1
Martins, A. J., Silva, P., Maciel, F., Pastrana, L. M., Cunha, R. L., Cerqueira, M. A., & Vicente, A. A. (2019). Hybrid gels: Influence of oleogel/hydrogel ratio on rheological and textural properties. Food Research International, 116, 1298–1305. https://doi.org/10.1016/j.foodres.2018.10.019
Paul, S. R., Qureshi, D., Yogalakshmi, Y., Nayak, S. K., Singh, V. K., Syed, I., … Pal, K. (2018). Development of Bigels Based on Stearic Acid-Rice Bran Oil Oleogels and Tamarind Gum Hydrogels for Controlled Delivery Applications. Journal of Surfactants and Detergents, 21(1), 17–29. https://doi.org/10.1002/jsde.12022
Kukhtenko, H., GladukhIe, Ye. V., Kukhtenko, O., Soldatov, D. (2017). Influence of Excipients on the Structural and Mechanical Properties of Semisolid Dosage Forms. Asian Journal of Pharmaceutics, 11(3), 575–578.
Davtian, L. L., Vashchuk, V. A., Polishchuk, Yu. P. (2013). Reolohichni doslidzhennia yak osnova tekhnolohichnoho protsesu u razi stvorennia novoho likarskoho zasobu. Farmatsevtychnyi zhurnal, 4, 52–58.
Karym, Z., Hladyshev, V., & Lysianska, A. (2018). Vyvchennia strukturno-mekhanichnykh vlastyvostei mazei z amineksylom. Aktualni pytannia farmatsevtychnoi ta medychnoi nauky ta praktyky, 3. http://dx.doi.org/10.14739/2409-2932.2018.3.144592
Downloads
Published
Issue
Section
License
Copyright (c) 2020 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).