Methodology of the development of combined drugs based on medicinal plant materials for mastopathy treatment
DOI:
https://doi.org/10.24959/uekj.20.10Keywords:
methodology, mastopathy, medicinal plant materialsAbstract
Aim. To create a scientific and methodological approach to combined drugs development of composition, technology and standardization for comprehensive scheme for the mastopathy treatment and prevention of breast cancer.
Results. According to the forecast of specialists from the National Cancer Institute, the diagnosis of breast cancer (DC) can become a reality for almost 17 % of women before the end of 2020, which gives reason to consider BC as a socially significant epidemiological problem. In the presence of proliferation in the mammary gland, mastopathy is considered to be a precancerous condition, and therefore, early diagnosis and timely, correctly selected treatment play a decisive role in maintaining the woman health. When developing a line of drugs based on medicinal plant material and phytosubstances, it is important to search for promising types of medicinal plant material (MPM) that will provide treatment for mastopathy, which will maximally cover all parts of the pathological process. For this purpose, it is necessary to carry out a detailed analysis of herbal remedies, which, due to a number of advantages, make it possible to provide a comprehensive approach to treatment, minimizing side effects. Summarizing the information obtained it will be able to formulate the basic requirements for the developed dosage forms: the presence of hormone-regulating, anti-inflammatory, reparative, restorative, absorbent action. To achieve this goal, a systematic and structural-logical analysis, comparative analysis and graphical data synthesis methods were used. In the process of research used methods of analysis of electronic and paper sources of information on providing the domestic pharmaceutical market with drugs for the treatment of mastopathy, directions and mechanism of their action, the possibility of using in the treatment of mastopathy of MPM with the content of biologically active compounds (BAC), affecting different pathogenetic processes, the possibility of combining it with synthetic active pharmaceutical ingredients (API) for the multipurpose treatment of mastopathy. The methodology algorithm consists of three blocks: information retrieval, research and biological. Each block that ends with an intermediate result provides a task for the next stage of the study.
Conclusions. A methodological approach that allows, on the basis of the algorithmic principle, to develop a line of combined original drugs based on medicinal plant materials, stable during storage, safe, but with specific activity for long-term use in the scheme of complex therapy of mastopathy, is proposed.
References
Tykhonovskyi, O. V. (2015). Aktualni pytannia farmatsevtychnoi i medychnoi nauky ta praktyky, 3(19), 81–86.
Potapov, V. A. (2016). Zdorove zhenshchiny, 1(107), 18–29.
Vyshnevska, L. I., Zuikina, C. C. (2015). Zbirnyk naukovykh prats spivrobitnykiv NMAPO imeni P.L. Shupyka, 24(5), 289–293.
Zuikina, S. S., Vyshnevska, L. I. (2018). Zbirnyk naukovykh prats spivrobitnykiv NMAPO im. P. L. Shupyka, 32, 285–294.
Zuikina, S. S. (2017). Suchasni dosiahnennia farmatsevtychnoi tekhnolohii i biotekhnolohii: zbirnyk naukovykh prats, 3. Kharkiv: NFaU, 114–119.
Zuikina, S. S., Vyshnevska, L. I. (2018). Advances of science : Proceedings of articles the international scientific conference. Czech Republic, Karlovy Vary – Ukraine, Kyiv, 630–641.
Dobronravov, I. S., Rudenko, O. V., Sydorenko, L. I. (2018). Metodolohiia ta orhanizatsiia naukovykh doslidzhen : navch. posibnik. Kyiv: VPTs «Kyivskyi universytet», 607.
Zujkina, S. S., & Vishnevska, L. I. (2017). The pharmacotechnological studies of the phytospecies composition for the complex therapy of mastopathy. Vìsnik Farmacìï, 2(90), 43–47. https://doi.org/10.24959/nphj.17.2172
Zuikina, S., Vishnevska, L. (2019). Research on the development of the basis of combined gel for mastopathy treatment. Mat. the 10th International Pharmaceutical Conference „Science and Practice 2019” is organized by Lithuanian University of Health Sciences, Faculty of Pharmacy. Kaunas, Lithuania, 107.
Derzhavna farmakopeya Ukrayiny. (2015). Derzhavne pidpryyemstvo «Ukrayins’kyy naukovyy farmakopeynyy tsentr yakosti likars’kykh zasobiv». Kharkiv: Derzhavne pidpryyemstvo «Ukrayins’kyy naukovyy farmakopeynyy tsentr yakosti likars’kykh zasobiv», 1, 1128.
Downloads
Published
Issue
Section
License
Copyright (c) 2020 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
