Technological aspects of the development of anti-viral activity nasal gel
DOI:
https://doi.org/10.24959/uekj.19.12Keywords:
technology, critical parameters, nasal gel, viral rhinitisAbstract
Today, there is a clear tendency among the Ukrainian population to increase the incidence of viral rhinitis. Among the nasal medicines of symptomatic action for this pathology treatment in the modern Ukrainian pharmaceutical market there are, mainly, synthetic drugs of foreign production, many of which are made in the form of drops or sprays. However, more and more attention is paid to nasal gels use, which ensure the maintenance of active ingredients on the nose mucous membrane, do not violate the movement of the flashing epithelium, maintain the natural moisture of the nasal mucosa and have prolonged therapeutic action.
Aim. To develop the technology of a new native nasal gel based on plant biologically active substances origin for the symptomatic treatment of viral rhinitis.
Materials and methods. The work uses physical-chemical, structural-mechanical, technological, microbiological and statistical methods.
Results. Based on the colloidal study, thermal stability, pH, rheological properties and osmotic activity of the studied gel samples, the rational concentrations of auxiliary substances in its composition were determined. Rational concentrations of active pharmaceutical ingredients (licorice root dry extract, Siberian pine and Eucalyptus essential oils) have been established based on microbiological studies. It is shown that the technology of nasal gel should consist of the base preparation and the active ingredients subsequent introduction. Taking into account the physical and chemical properties of active pharmaceutical ingredients, namely their solubility, licorice root dry extract are introduced into the gel in the form of aqueous solution, and essential oils – in the form of a solution in ethanol (96 %).
Conclusions. Based on the complex of conducted experimental researches, rational technology of nasal gel under the conventional name “Phytorin-plus” was developed. The critical parameters in the process of its production (time of homogenization – 20 min, speed of the blade mixer rotation – 42 rpm, speed of the anchor mixer rotation – 20 rpm, the vacuum depth – 0.6-0.7 bar) were established.
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