Investigation of in vitro permeability of ketorolac tromethamine through a semipermeable membrane in the process of pharmaceutical development of transdermal therapeutic system
DOI:
https://doi.org/10.24959/uekj.18.5Keywords:
in vitro permeability, ketorolac tromethamine, transdermal therapeutic systemAbstract
Nowadays in the world practice of pharmaceutical production, there has been a recent increase of producing controlled-release medicines, primarily transdermal therapeutic systems (TTs).
Aim. To investigate the in vitro ketorolac tromethamine permeability during the pharmaceutical development of the transdermal dosage form of this medical substance, to determine of the quantitative parameters of the process and to analyze the possibility of developing TTS for anti-inflammatory and analgesic activity.
Materials and methods. The API in vitro permeability study through cellophane membrane was carried out by dialysis using a Valia-Chien diffusion device.
Results. The processes of in vitro ketorolac tromethamine penetration through the semipermeable membrane are investigated. The basic kinetic parameters of the process are determined. The scientific methodological approaches to the development of a transdermal therapeutic system are considered.
Conclusions. The analysis of character, description of the mathematical model and determination of the kinetic parameters of the permeability process of the investigated medical substance of the ketorolac tromethamine allow to assess its potential for the creation of TTS and to substantiate the further algorithm for the development of TTS anti-inflammatory and analgesic action with this API.
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