Question introduction to the State Pharmacopoeia of Ukraine monograph «Devil’s claw root»
DOI:
https://doi.org/10.24959/uekj.18.3Keywords:
standardization, medicinal plant material, roots of Harpagophytum procumbens, State Pharmacopoeia of UkraineAbstract
The roots of Harpagophytum procumbens are the imported raw material on the territory of Ukraine, however a wide range of herbal drugs are based on it. Because of this conduct research works on verification of quality control techniques of the monograph «Devil’s claw root», which was included in the State Pharmacopoeia of Ukraine (SPhU) 2.0 for established of the relevance of the introduction of national requirements are need.
Aim. To carry out experimental works on the verification of identification methods and quantitative determination of the active substances in the roots of Harpagophytum procumbens according to the requirements of the monograph of the European Pharmacopoeia (EPh) and SPhU 2.0.
Materials and methods. Raw materials of Harpagophytum procumbens. The research was carried out by the way of determination the macroscopic, microscopic and quality indicators.
Results. Studies showed that the roots of Harpagophytum procumbens, in the case determination of macroscopic, microscopic indicators, quality indicators such as: «Loss of drying», «Total ash», «Starch», qualitative and quantitative determination of biologically active substances (BAS) meet regulatory documentation – monographs EPh 8.0 and SPhU 2.0 «Devil’s claw Root».
Conclusions. The data obtained indicate that the raw materials of Harpagophytum procumbens meet the requirements of EPh and SPhU 2.0. The results of the studies have been taken for the development of the monograph SPhU 2.0 «Devil’s claw Root», which is presented without the introduction of additional national parts.
References
Derzhavnyi reiestr likarskykh zasobiv Ukrainy. Available at: http://www.drlz.kiev.ua/
Chrubasik, J. E., Roufogalis, B. D., Chrubasik, S. (2007). Evidence of effectiveness of herbal antiinflammatory drugs in the treatment of painful osteoarthritis and chronic low back pain. Phytotherapy Research, 21 (7), 675–683. doi: 10.1002/ptr.2142
Vlachojannis, J., Roufogalis, B. D., Chrubasik, S. (2008). Systematic review on the safety ofHarpagophytum preparations for osteoarthritic and Low back pain. Phytotherapy Research, 22 (2), 149–152. doi: 10.1002/ptr.2314
Mncwangi, N., Chen, W., Vermaak, I., Viljoen, A. M., Gericke, N. (2012). Devil’s Claw – a review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens. J Ethnopharmacol., 143 (3), 755–71. doi: 10.1016/j.jep.2012.08.013
Benito, P., Lanza, A., Sen, A., De Santos Galindez, J., Matellano, L., Gómez, A., Martínez, M. (2000). Effects of Some Iridoids from Plant Origin on Arachidonic Acid Metabolism in Cellular Systems. Planta Medica, 66 (04), 324–328. doi: 10.1055/s–2000–8549
Chrubasik, S., Junck, H., Breitschwerdt, H., Conradt, C., Zappe, H. (1999). Effectiveness of Harpagophytum extract WS 1531 inthe treatment of exacerbation of low back pain: a randomized, placebo–controlled, double–blind study. European Journal of Anaesthesiology, 16 (2), 118–129. doi: 10.1097/00003643–199902000–00008
Babili, F., Fouraste, I., Rougaignon, C., Moulis, C., Chatelain, C. (2012). Anatomical study of secondary tuberized roots of Harpagophytum procumbens DC and quantification of harpagoside by high–performance liquid chromatography method. Pharmacognosy Magazine, 8 (30), 175. doi: 10.4103/0973–1296.96587
Qi, J., Chen, J.–J., Cheng, Z.–H., Zhou, J.–H., Yu, B.–Y., Qiu, S. X. (2006). Iridoid glycosides from Harpagophytum procumbens D.C. (devil’s claw). Phytochemistry, 67 (13), 1372–1377. doi: 10.1016/j.phytochem.2006.05.029
Grizodub, A. I., Georgievskii, G. V., Tikhonenko, T. M., Georgievskii, V. P. (2004). Farmakom – Pharmacom, 4, 3–17.
European Pharmacopoeia, 8.0th ed. (2014).Strasbourg: European Department for the Quality of Medicines, 1126–1227.
Grizodub, A. I., Evtifeeva, O. A., Proskurina, K. I. (2012). Farmakom – Pharmacom, 3, 7–30.
Downloads
Published
Issue
Section
License
Copyright (c) 2018 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).