Analysis of assortment and availability indicators of spasmolytic drugs for gastrointestinal tract functional disorders in Ukraine
DOI:
https://doi.org/10.24959/uekj.18.15Keywords:
spasmolytic drugs, drugs assortment analysis, INN, price, availability of drugs, indicator of Ca.s.Abstract
Gastrointestinal tract (GIT) functional disorders are one of the most urgent problems in modern gastroenterology, which is due to the widespread nature of this pathology and the problems associated with it. They form a group of heterogeneous (different in nature and origin) clinical states, manifested by various symptoms and disorders of gastrointestinal tract functions, and are not accompanied by structural, metabolic or systemic changes. According to the results of numerous epidemiological studies, up to 50-60 % of adults and up to 30-40 % of children who apply to gastroenterologists suffer from various functional disorders in the digestive system. The World Health Organization (WHO) states: over the past 60 years, the incidence of these disorders has increased 24-fold.
Aim. To analyze the range, prices and availability indicator Ca.s. of anesthetic drugs in Ukraine during 2014-2016, and to determine the dynamics of these characteristics for the study period.
Results. In 2016 there were 9 INN on the Ukrainian pharmaceutical market , 69 trade names (TN) of drugs were detected. The structural analysis of antispasmodics assortment (2016) showed the largest TN assortment is characteristic of INN: Drotaverin – 30 TN; Simethicone – 16 TN; Papaverine – 10 TN. Medicines are presented on the market in a wide assortment and in an affordable price range, which enables the physician to choose a drug based on its effectiveness and safety. Spasmolytics are presented in a variety of forms: tablets, capsules, syrups, rectal suppositories, oral drops (in the form of emulsions), and solutions / suspensions for the preparation of injections. The most common form of release in this pharmacological group is the pill. In the process of analysis the antispasmodics drugs assortment during the period of 2014-2016, a tendency was observed in the decreased number of foreign manufactured medicines, but there was a slight increase in domestic drug production. By the indicator of economic availability, most generic drugs used for treatment functional disorders in gastrointestinal tract, are highly available. In most cases, imported medicines are in average availability. Conclusions. During the three years studies, the number of domestic generic drugs increased, which are more accessible to Ukrainian consumers, and the number of imported medicines is slightly decreased. The range of prices varied from low to high, and this gave the opportunity to individually choose drugs based on the active ingredients, dosage forms and prices. It ranged from 4.35 to 266.31 UAH, and within the limits of one INN Drotaverin. The study of antispasmodic drugs availability allowed us to establish the vast majority of SLS is represented by highly available medicines, and only some of the INNs are mediated by spasmolytic action medications of mebeverine, drotaverin and pinaverium bromide.
References
Chystyk, T. (2013). Hazeta «Novyny medytsyny ta farmatsii» Gastroenterolohiia, 446.
Sirchak, Ye. S. (2016). Funktsionalna dyspepsiia u pryzmi Rymskykh kryteriiv IV. Available at : http://health–
ua.com/article/4316–funktconalna–dispepsya––uprizm–rimskih–kriterv–V
Farmatsevtychnyi visnyk. Available at: http://mediclab.com.ua/index.php?newsid=14126
Kryvenko, V. I., Hrinenko, T. Yu., Pakhomova, S. T. (2015). Funktsionalni rozlady shlunkovo–kyshkovoho
traktu u praktytsi likaria zahalnoi praktyky – simeinoi medytsyny. Zaporizhzhia, 89.
Syndrom podraznenoho kyshechnyka. Prychyny, symptomy, diagnostyka ta efektyvne likuvannia. Available
at: https://www.polismed.com/articles–sindrom–razdrazhennogo–kishechnika–01.html
Trohymchuk, V. V., Kyrpach, O. V. (2015). Farmatsevtychnyi zhurnal, 5, 5–8.
Programnyi kompleks «Apteka» kompanii «Morion». Available at: NTG:// pharmbase.com.ua/poisk
Downloads
Published
Issue
Section
License
Copyright (c) 2018 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).