Quantitative determination of Ibuprofen by chemiluminescent method

N. Yu. Bondarenko, M. Ye. Blazheyevskiy

Abstract


Aim. The development of quantitative determination of Ibu using a new analytical system H2L (luminol) – H2O2 – Hb (hemoglobin), where Ibu is chemiluminescence inhibitor.

Materials and Methods. The objects of research were: the  substance of Ibuprofen and drugs containing Ibuprofen: the tablets of “Ibuprofen” produced by PC “Technolog” (Uman, Ukraine) and the tablets “Nurofen” was covered the shell produced by Reckitt Benckiser Healthcare International Limited, Thane Road, Nottingham, Nottinghamshire, United Kingdom. The intensity of chemiluminescence was measured on the device with “Chemiluminometer – CL 01” photoelectric multiplier FEU-84-A, using measurement of low currents IMT-0.5 and quick-acting automatic potentiometer.

Results. The method of Ibuprofen was studied and showed the quantitative determination in tablets based on reaction of inhibition of chemilumeniscence system H2LH2O2 Hb. RSD ± 1.56 % (δ = –0.75 %) and ±1.68 % (δ = –0.35 %) for the tablets of “Ibuprofen” and the tablets of “Nurofen” tablets respectively, LOQ is 3·10–5 mol·L–1.

Conclusions. The proposed method is promising for further research for their application, for the determination of small amounts of Ibuprofen in the wash water, when washing control equipment held on pharmaceutical companies.


Keywords


Ibuprofen; luminol; inhibitor; chemilumeniscence method

References


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GOST Style Citations


1. Bondarenko, N. Yu., Blazheievskii, M. Ye. (2016). Ukrainskyi biofarmatsevtychnyi zhurnalUkrainian biopharmaceutical journal, 44, (3), 14–17.

2. Blazheievskii, M. Ye., Bondarenko, N. Yu., Ivashura, M. M. (2012). Ukrainskyi medychnyi almanakhUkrainian medical almanac, 15, (6), 24–26.

3. State Pharmakopeia of Ukraine. (2001). Kharkiv, 556.

4. Kaczmarek, M., Lis, S. (2012). Chemiluminescence determination of ibuprofen and ketoprofen using the Fenton system in the presence of europium(III) ions. Analytical Methods, 4, 1964. doi: 10.1039/c2ay25230a

5. Khoshayand, M. R., Abdollahi, H., Shariatpanahi, M. (2008). Simultaneous spectrophotometric determination of paracetamol, ibuprofen and caffeine in pharmaceuticals by chemometric methods. Spectrochimica Acta, 70, (3), 491–499. doi: 10.1016/j.saa.2007.07.033

6. Li, Y., Lu, J. (2007). Direct chemiluminescence determination of ibuprofen by the enhancement of the KMnO4–sulphite reaction. Luminescence, 22, (4), 326–330. doi: 10.1002/bio.966

7. Selivanova, N., Vasilieva, K., Galyametdinov, Yu. (2014). Luminescent complexes of terbium ion for molecular recognition of ibuprofen. Luminescence, 29, (3), 202–210. doi: 10.1002/bio.2526

8. Shaalan, R. A., Haggag, R. S., Belal, S. F. (2013). Simultaneous determination of hyoscine, ketoprofen and ibuprofen in pharmaceutical formulations by HPLC–DAD. Journal of Applied Pharmaceutical Science, 3, (7), 38–47. 





DOI: https://doi.org/10.24959/uekj.17.1

Abbreviated key title: Upr. ekon. zabezp. âkostì farm.

ISSN 2519-8807 (Online), ISSN 2311-1127 (Print)